Members in Ck

Basic research team

Heein Yoon, RDH, PhD

Heein Yoon, RDH, PhD

Dr. Heein Yoon is a postdoctoral researcher of department of molecular genetics at Seoul National University. She has been conducting various researches regarding to the effect of nicotinamide, an amide derivate of vitamin B3, in bone metabolism. Dr. Yoon proposed underlying molecular mechanism of nicotinamide for the treatment of delayed tooth eruption by using the Runx2+/- murine model, a well-established animal model of cleidocranial dysplasia. She also reported that nicotinamide enhances osteogenic differentiation through the activation of mitochondrial antioxidant defense system. Recently, she is interested in research based on bioinformatics-based study to uncover intracellular changes during the bone metabolism process.

Education and Training

  • Postdoctoral Researcher, School of Dentistry and Dental Research Institute, Seoul National University

  • Ph.D. in Molecular Genetics, School of Dentistry, Seoul National University, Korea

  • B.S. in Dental Hygiene, Wonju College of Medicine, Yonsei University, Korea

Publications

  • Yoon H, Park SG, Kim HJ, Shin HR, Kim KT, Cho YD, Moon JI, Park MS, Ryoo HM. Nicotinamide enhances osteoblast differentiation through the activation of mitochondrial antioxidant system. Exp Mol Med. 2023. (In press)

  • Kim HJ, Kim WJ, Shin HR, Yoon HI, Moon JI, Lee E, Lim JM, Cho YD, Lee MH, Kim HG, Ryoo HM. ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation. Cell Mol Life Sci. 2022 Feb 26;79(3):155. doi: 10.1007/s00018-022-04186-5. PMID: 35218410; PMCID: PMC8882118.

  • Shin HR, Kim BS, Kim HJ, Yoon H, Kim WJ, Choi JY, Ryoo HM. Excessive osteoclast activation by osteoblast paracrine factor RANKL is a major cause of the abnormal long bone phenotype in Apert syndrome model mice. J Cell Physiol. 2022 Apr;237(4):2155-2168. doi: 10.1002/jcp.30682. Epub 2022 Jan 20. PMID: 35048384; PMCID: PMC9303724.

  • Yoon H, Kim HJ, Shin HR, Kim BS, Kim WJ, Cho YD, Ryoo HM. Nicotinamide Improves Delayed Tooth Eruption in Runx2+/- Mice. J Dent Res. 2021 Apr;100(4):423-431. doi: 10.1177/0022034520970471. Epub 2020 Nov 3. PMID: 33143523.

  • Kim BS, Shin HR, Kim HJ, Yoon H, Cho YD, Choi KY, Choi JY, Kim WJ, Ryoo HM. Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome. Sci Rep. 2021 Apr 12;11(1):7979. doi: 10.1038/s41598-021-87260-5. PMID: 33846505; PMCID: PMC8041873.

  • Kim B, Shin H, Kim W, Kim H, Cho Y, Yoon H, Baek J, Woo K, Lee Y, Ryoo H. PIN1 Attenuation Improves Midface Hypoplasia in a Mouse Model of Apert Syndrome. J Dent Res. 2020 Feb;99(2):223-232. doi: 10.1177/0022034519893656. Epub 2019 Dec 23. PMID: 31869252.

  • Kim WJ, Kim BS, Kim HJ, Cho YD, Shin HL, Yoon HI, Lee YS, Baek JH, Woo KM, Ryoo HM. Intratesticular Peptidyl Prolyl Isomerase 1 Protein Delivery Using Cationic Lipid-Coated Fibroin Nanoparticle Complexes Rescues Male Infertility in Mice. ACS Nano. 2020 Oct 27;14(10):13217-13231. doi: 10.1021/acsnano.0c04936. Epub 2020 Oct 7. PMID: 32969647.

  • Islam R, Yoon H, Shin HR, Bae HS, Kim BS, Yoon WJ, Woo KM, Baek JH, Lee YS, Ryoo HM. Peptidyl-prolyl cis-trans isomerase NIMA interacting 1 regulates skeletal muscle fusion through structural modification of Smad3 in the linker region. J Cell Physiol. 2018 Dec;233(12):9390-9403. doi: 10.1002/jcp.26774. Epub 2018 Aug 21. PMID: 30132832; PMCID: PMC6686165.

  • Shin HR, Bae HS, Kim BS, Yoon HI, Cho YD, Kim WJ, Choi KY, Lee YS, Woo KM, Baek JH, Ryoo HM. PIN1 is a new therapeutic target of craniosynostosis. Hum Mol Genet. 2018 Nov 15;27(22):3827-3839. doi: 10.1093/hmg/ddy252. PMID: 30007339; PMCID: PMC6216213.

  • Islam R, Yoon H, Kim BS, Bae HS, Shin HR, Kim WJ, Yoon WJ, Lee YS, Woo KM, Baek JH, Ryoo HM. Blood-testis barrier integrity depends on Pin1 expression in Sertoli cells. Sci Rep. 2017 Aug 1;7(1):6977. doi: 10.1038/s41598-017-07229-1. PMID: 28765625; PMCID: PMC5539286.

  • Yoon H, Park J, Park KK, Kim J, Bandara NC, Bandara BMR, Tilakaratne WM, Chung WY. Methanol Extract of Holarrhena antidysenterica Inhibits the Growth of Human Oral Squamous Cell Carcinoma Cells and Osteoclastogenesis of Bone Marrow Macrophages. Evid Based Complement Alternat Med. 2017;2017:7272947. doi: 10.1155/2017/7272947. Epub 2017 Nov 22. PMID: 29358968; PMCID: PMC5735661.

  • Lee SK, Park KK, Kim HJ, Kim KR, Kang EJ, Kim YL, Yoon H, Kim YS, Chung WY. Platycodin D Blocks Breast Cancer-Induced Bone Destruction by Inhibiting Osteoclastogenesis and the Growth of Breast Cancer Cells. Cell Physiol Biochem. 2015;36(5):1809-20. doi: 10.1159/000430152. PMID: 26184636.