Members in Ck

Basic research team

Hye-Rim SHIN, PhD

Hye-Rim SHIN, PhD

Dr. Hye-Rim SHIN is a Senior Researcher in Department of Molecular Genetics at Seoul National University School of Dentistry. She has conducted numerous investigations on the PTM procedure, which is involved in a number of cells signaling mechanisms that regulate bone development. In particular, she mainly conducted her research to recover genetic diseases caused by gene mutation through drug treatment of PTM regulation. She is also focusing on the molecular genetics and bioinformatics applications of H19, one of the long non-coding RNAs that has not been extensively explored, in bone aging.

Education and Training

  • Ph.D. in Molecular Genetics, College of Dentistry, Seoul National University, Korea

  • B.S. in Biochemistry, College of Natural Sciences, Chungbuk National University, Korea

Publications

  • Shin HR, Kim BS, Kim HJ, Yoon HI, Kim WJ, Choi JY, Ryoo HM. Excessive osteoclast activation by osteoblast paracrine factor RANKL is a major cause of the abnormal long bone phenotype in Apert syndrome model mice. Journal of Cellular Physiology. 2022;237(4), 2155-2168, doi:https://doi.org/10.1002/jcp.30682

  • Kim HJ, Kim WJ, Shin HR, et al. ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFkappaB activation. Cell Mol Life Sci. 2022;79(3):155.

  • Yoon, H.; Kim, H.J.; Shin, H.R.; Kim, B.S.; Kim, W.J.; Cho, Y.D.; Ryoo, H.M. Nicotinamide Improves Delayed Tooth Eruption in Runx2(+/-) Mice. J. Dent. Res. 2021, 100, 423-431, doi:10.1177/0022034520970471.

  • Kim, B.S.; Shin, H.R.; Kim, H.J.; Yoon, H.; Cho, Y.D.; Choi, K.Y.; Choi, J.Y.; Kim, W.J.; Ryoo, H.M. Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome. Sci. Rep. 2021, 11, 7979, doi:10.1038/s41598-021-87260-5.

  • Yoon, H.; Kim, H.J.; Shin, H.R.; Kim, B.S.; Kim, W.J.; Cho, Y.D.; Ryoo, H.M. Nicotinamide Improves Delayed Tooth Eruption in Runx2(+/-) Mice. J. Dent. Res. 2020, 10.1177/0022034520970471, 22034520970471, doi:10.1177/0022034520970471.

  • Kim, W.J.; Kim, B.S.; Kim, H.J.; Cho, Y.D.; Shin, H.R.; Yoon, H.I.; Lee, Y.S.; Baek, J.H.; Woo, K.M.; Ryoo, H.M. Intratesticular Peptidyl Prolyl Isomerase 1 Protein Delivery Using Cationic Lipid-Coated Fibroin Nanoparticle Complexes Rescues Male Infertility in Mice. Acs Nano 2020, 14, 13217-13231, doi:10.1021/acsnano.0c04936.

  • Kim B, Shin H, Kim W, Kim H, Cho Y, Yoon H, Baek J, Woo K, Lee Y, Ryoo H. 2020. Pin1 attenuation improves midface hypoplasia in a mouse model of apert syndrome. J Dent Res. 99(2):223-232.

  • Shin HR, Bae HS, Cho YD, et al. PIN1 is a new therapeutic target of craniosynostosis. Hum Mol Genet. 2018.

  • Shin HR, Islam R, Yoon WJ, Lee TK, Cho YD, Bae HS, Kim BS, Woo KM, Baek JH, and Ryoo HM (2016) Pin1-mediated Modification Prolongs the Nuclear Retention of beta-Catenin in Wnt3a-induced Osteoblast Differentiation. J Biol Chem. 291(11), 5555-5565

  • Yoon WJ, Islam R, Cho YD, Ryu KM, Shin HR, Woo KM, Baek JH, and Ryoo HM (2015) Pin1 plays a critical role as a molecular switch in canonical BMP signaling. J Cell Physiol. 230(3), 640-647

Patents

  • “Pharmaceutical composition for preventing or treating bone disease.” (Korea,10-2018-0111315)

National Research Grants

  • 2022~2025 Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number) (NRF-2022R1I1A1A01053914 ) ‘Identification of the role and mechanism of long noncoding RNA (lncRNA) H19 as the therapeutic target for bone regeneration in aging’

  • 2018~2021 National Research Foundation of Korea (NRF) No. 2018R1A6A3A01012572 ‘The validation of a novel therapeutic target for the Apert syndrome; Pin1, a peptidyl prolyl isomerase’

Awards and Honors

  • 2018, Plenary Poster award, 2018 American Society for Bone and Mineral Research (ASBMR)

  • 2016, Young investigator Award, 2016 American Society for Bone and Mineral Research (ASBMR)